Immuno-oncology biotech using AI-driven antibody design and protein modeling
SystImmune develops bi-specific, tri-specific, and antibody-drug conjugate therapeutics targeting solid tumors, with a tech stack revealing a shift toward computational drug discovery. The company runs AlphaFold, ProteinMPNN, and LLaMA alongside traditional biotech instrumentation (UPLC, HPLC, Leica microscopy), and is actively building scalable ML models and a computational protein design pipeline — signaling a move from pure bench biology toward AI-assisted target identification and therapeutic design. Hiring velocity is accelerating with research roles dominating (32 of 65 filled), but a notable leadership gap in senior biostatistics and quality functions suggests growing complexity in data and regulatory workflows.
Notable leadership hires: Analytical Director, Biostatistics Director, Head of Quality
SystImmune is a Redmond-based immuno-oncology biotech founded in 2014, operating at 51–200 employees with a focus on novel antibody therapeutics and antibody-drug conjugates for solid tumors. The company works through two mechanisms: direct tumor targeting and immune system activation. The tech stack spans research instrumentation (UPLC, HPLC, AlphaFold, ProteinMPNN), data infrastructure (Spotfire, SAS, R, Python, Dask, Ray), and lab information management (LIMS, CDISC). Active projects span immuno-oncology discovery, technology transfer to clinical manufacturing, computational protein design, and biomarker assay development (IHC, CDX). The company is hiring across research, data, healthcare, and regulatory functions, with recruiting and technology transfer scaling as near-term constraints.
SystImmune uses AlphaFold, ProteinMPNN, LLaMA, LangChain, and Python for computational protein design and AI-driven target identification, alongside traditional biotech tools (UPLC, HPLC) and biostatistics platforms (SAS, R, Spotfire).
SystImmune is scaling immuno-oncology discovery and preclinical projects, building a computational protein design pipeline, developing AI-driven therapeutic discovery, and managing technology transfer to clinical manufacturing while expanding regulatory and quality operations.
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