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SystImmune Tech Stack

Immuno-oncology biotech using AI-driven antibody design and protein modeling

Biotechnology Research Redmond, Washington 51–200 employees Founded 2014 Privately Held

SystImmune develops bi-specific, tri-specific, and antibody-drug conjugate therapeutics targeting solid tumors, with a tech stack revealing a shift toward computational drug discovery. The company runs AlphaFold, ProteinMPNN, and LLaMA alongside traditional biotech instrumentation (UPLC, HPLC, Leica microscopy), and is actively building scalable ML models and a computational protein design pipeline — signaling a move from pure bench biology toward AI-assisted target identification and therapeutic design. Hiring velocity is accelerating with research roles dominating (32 of 65 filled), but a notable leadership gap in senior biostatistics and quality functions suggests growing complexity in data and regulatory workflows.

Tech Stack 29 technologies

Core StackLangChain MariaDB AWS NetSuite SAS Python Hugging Face Ollama Spotfire LLaMA ProteinMPNN Milvus Dask Ray MPI LIMS SQL Excel AlphaFold Microsoft Office LinkedIn R Leica CDISC PowerPoint UPLC HPLC Concur

What SystImmune Is Building

Challenges

  • Scaling hr practices
  • Ensuring data integrity and regulatory compliance
  • Technology transfer from research to manufacturing
  • Identifying novel drug targets
  • Design next-generation therapeutics
  • Expanding recruiting capacity
  • Data cleaning and reporting for new drug discovery
  • Integration of analytical workflows
  • Managing clinical supplies
  • Tracking subject recruitment

Active Projects

  • Immuno-oncology discovery/preclinical projects
  • Scalable interpretable ml model development
  • Technology transfer to clinical manufacturing
  • Initial growth phase recruiting
  • Onboarding and culture building initiatives
  • Computational protein design pipeline
  • Sop development
  • Therapeutic design
  • Ihc assay & cdx development
  • Ai-driven therapeutic discovery pipeline

Hiring Activity

Accelerating70 roles · 35 in 30d

Department

Research
32
Data
8
Healthcare
7
HR
5
Finance
4
Manufacturing
3
Ops
3
Regulatory
3

Seniority

Senior
31
Mid
16
Director
13
Manager
3
Junior
2
Lead
2
Principal
2

Notable leadership hires: Analytical Director, Biostatistics Director, Head of Quality

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About SystImmune

SystImmune is a Redmond-based immuno-oncology biotech founded in 2014, operating at 51–200 employees with a focus on novel antibody therapeutics and antibody-drug conjugates for solid tumors. The company works through two mechanisms: direct tumor targeting and immune system activation. The tech stack spans research instrumentation (UPLC, HPLC, AlphaFold, ProteinMPNN), data infrastructure (Spotfire, SAS, R, Python, Dask, Ray), and lab information management (LIMS, CDISC). Active projects span immuno-oncology discovery, technology transfer to clinical manufacturing, computational protein design, and biomarker assay development (IHC, CDX). The company is hiring across research, data, healthcare, and regulatory functions, with recruiting and technology transfer scaling as near-term constraints.

HeadquartersRedmond, Washington
Company Size51–200 employees
Founded2014
Hiring MarketsUnited States, China

Frequently Asked Questions

What technologies does SystImmune use for drug discovery?

SystImmune uses AlphaFold, ProteinMPNN, LLaMA, LangChain, and Python for computational protein design and AI-driven target identification, alongside traditional biotech tools (UPLC, HPLC) and biostatistics platforms (SAS, R, Spotfire).

What is SystImmune working on?

SystImmune is scaling immuno-oncology discovery and preclinical projects, building a computational protein design pipeline, developing AI-driven therapeutic discovery, and managing technology transfer to clinical manufacturing while expanding regulatory and quality operations.

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