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Personalis, Inc. Tech Stack

Ultrasensitive cell-free DNA testing for minimal residual disease detection

Biotechnology Research Fremont, California 201–500 employees Founded 2011 Public Company

Personalis operates a clinical diagnostics business centered on circulating tumor DNA (ctDNA) assays for cancer monitoring and therapy selection. The tech stack reveals a hybrid infrastructure approach: LIMS and lab automation tools (Qubit, qPCR, TapeStation) paired with cloud analytics (AWS, GCP) and BI platforms (Tableau, Power BI), suggesting active effort to modernize legacy lab systems while scaling data processing. Active projects span assay development, LIMS optimization, and continuous delivery, while pain points cluster around operational friction—turnaround time, claim rejections, payment delays—pointing to a business hitting scaling challenges in a regulated, high-throughput setting.

Tech Stack 31 technologies

Core StackSalesforce Python Tableau Power BI VMware AWS Active Directory Java Linux GitHub Service Cloud LIMS R Excel QAD SQL Cisco Nexus Cisco Meraki Dell VxRail VAST Data Dell Isilon GCP AWS Direct Connect Red Hat Enterprise Linux Ubuntu CentOS TapeStation Qubit qPCR Git+1 more

What Personalis, Inc. Is Building

◆Challenges

Reducing turnaround time
Claim rejection rates
Payment processing delays
Quality control failures
Adoption of novel ctdna technologies
Engaging key opinion leaders
Legacy lims platforms
Lab automation integration
24/7 laboratory operations
Reducing production issues

▲Active Projects

Next personal mrd assay
Assay development
Sales forecasting process
Profiling patient response to therapy with cfdna platforms
Key opinion leader engagement
Clinical advocacy & education
Cell-free platform development
Lims optimization and integration
Legacy system evolution
Continuous delivery implementation

Hiring Activity

Steady40 roles · 15 in 30d

Department

Healthcare

11

Research

5

Engineering

3

Finance

3

Ops

3

Data

2

Marketing

2

Sales

2

Seniority

Junior

13

Mid

12

Senior

8

Director

3

Manager

2

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About Personalis, Inc.

Personalis is a public genomics company developing ultrasensitive ctDNA testing assays for cancer management, including minimal residual disease (MRD) detection and therapy selection guidance. The product relies on tumor-and-normal profiling combined with proprietary algorithms to track disease evolution over a patient's treatment journey. The company serves oncologists and drug developers across clinical and R&D settings. Operations are based in Fremont, California, with a workforce of 201–500 employees structured around healthcare (largest hiring cohort), research, and engineering functions. Current hiring reflects a healthcare-focused, operationally maturing organization navigating both technical scaling (LIMS, continuous delivery) and commercial challenges (claims, payment cycles).

HeadquartersFremont, California

Company Size201–500 employees

Founded2011

Hiring MarketsUnited States

Frequently Asked Questions

What is Personalis' main product?

Personalis develops ultrasensitive circulating tumor DNA (ctDNA) assays for detecting minimal residual disease and guiding cancer therapy selection. Assays combine tumor-and-normal profiling with proprietary algorithms to track disease over time.

What tech stack does Personalis use?

Lab and sequencing tools (Qubit, qPCR, TapeStation, LIMS), cloud infrastructure (AWS, GCP, AWS Direct Connect), data analytics (Tableau, Power BI), bioinformatics languages (Python, R, SQL), and networking (Cisco Nexus, Meraki).