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OpenEye, Cadence Molecular Sciences Tech Stack
Cloud-native computational chemistry platform for drug discovery
OpenEye (acquired by Cadence in 2022) builds Orion, a cloud-native molecular design platform centered on 3D shape and electrostatics analysis. The tech stack is heavily weighted toward web infrastructure (Vue, Nuxt, Next.js, WebGL, WebAssembly) layered over C++ and Python backends on AWS, signaling a shift from desktop-first tooling toward browser-native interfaces. Active projects span molecular dynamics, binding affinity prediction, and ML-driven screening—all pointing toward automated, high-throughput workflows rather than manual analysis.
Tech Stack 27 technologies
Core StackAWS C++ Python JavaScript TypeScript Vue Next.js Sketch Figma InVision Django Go PostgreSQL Docker Salesforce Pinia Vuex Nuxt Web Workers WebAssembly WebGL Balsamiq pytest SQLite Cadence CMake TeamCity
What OpenEye, Cadence Molecular Sciences Is Building
◆Challenges
- Modernizing existing software
- Higher throughput md-based prescreening
- Modernizing legacy ui
- Enhancing orion's capabilities
- Optimizing high-performance compute and storage systems
- Scaling binding free energy workflows
- Scalable biologics drug discovery solutions
- Advancing computational biologics drug discovery
- Modernizing build infrastructure
- Maintaining multi-platform build configurations
▲Active Projects
- Develop scalable workflows for relative binding free energy in lead optimization
- Explore 3d-qsar machine learning models using large-scale relative binding free energy calculations
- Higher throughput md-based prescreening
- Building cutting edge features
- Modernizing existing software
- Software evaluations with application scientists
- Md-based solutions for predicting protein-ligand binding affinities
- Enhancing orion ui
- Scalable biologics drug discovery solutions
- Architecting compute and storage systems
Hiring Activity
15 roles · 15 in 30d
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