OpenEye, Cadence Molecular Sciences Tech Stack

Cloud-native molecular design platform for drug discovery

Software Development Santa Fe, NM 51–200 employees Founded 1997 Public Company

OpenEye builds Orion, a cloud-based computational chemistry platform for pharma and biotech R&D. The tech stack—Vue, Nuxt, Next.js, WebGL, WebAssembly, C++, Python on AWS—reflects a frontend-heavy, visualization-first architecture optimized for 3D molecular rendering and interactive analysis. Active projects span UI modernization, molecular dynamics simulation, and cryptic pocket detection workflows, while repeated mentions of modernizing legacy systems suggest the team is actively rebuilding core components to scale computational workloads in the cloud.

Tech Stack 15 technologies

Core StackVue Next.js JavaScript TypeScript Python AWS C++ Pinia Vuex Nuxt CSS HTML Web Workers WebAssembly WebGL

What OpenEye, Cadence Molecular Sciences Is Building

◆Challenges

Modernizing existing software
Modernizing legacy ui

▲Active Projects

Enhancing orion ui capabilities
Workflow for connecting cryptic-pocket detection to functional interpretation
Modernizing existing software
Small molecule drug discovery software development
New product & feature development
Building cutting edge features
Algorithmic framework for predicting allosteric effects
Md simulation insights for drug molecules
Discover cryptic pockets via wemd
Free energy calculations and molecular dynamics simulations

Hiring Activity

Steady10 roles · 4 in 30d

Department

Engineering

Research

Seniority

Intern

Principal

Mid

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About OpenEye, Cadence Molecular Sciences

OpenEye, acquired by Cadence Design Systems in 2022, specializes in computational tools for molecular design and drug discovery. The company has operated for over 25 years and serves pharma and biotech organizations worldwide, with offices in Santa Fe, Boston, Cologne, and Tokyo. Orion consolidates shape and electrostatics analysis, virtual screening, free energy calculations, and molecular dynamics simulation into a single SaaS platform. The focus is on enabling scientists to visualize, analyze, and optimize small-molecule structures at scale using cloud infrastructure.

HeadquartersSanta Fe, NM

Company Size51–200 employees

Founded1997

Hiring MarketsUnited States, United Kingdom, India

Frequently Asked Questions

What tech stack does OpenEye use?

Vue, Nuxt, Next.js, JavaScript, TypeScript, Python, C++, WebGL, WebAssembly, and AWS. The stack emphasizes browser-based 3D visualization and computational chemistry workloads.

Is OpenEye hiring engineers?

Yes. Active roles span engineering, with positions posted in the United States, United Kingdom, and India across intern, mid, and principal levels.

Where is OpenEye headquartered?

Santa Fe, New Mexico. The company also maintains offices in Boston, Cologne, and Tokyo.