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Calico Life Sciences Tech Stack

AI-driven drug discovery and aging biology research platform

Biotechnology Research South San Francisco, CA 201–500 employees Founded 2013 Privately Held

Calico is an Alphabet-backed biotech R&D lab focused on understanding human aging mechanisms and translating that science into therapeutics. The technical stack—PyTorch, TensorFlow, JAX, AlphaFold, plus wet-lab tools like LC-MS, qPCR, HPLC—reflects a hybrid operation: computational protein design and ML model validation running alongside traditional drug discovery workflows. The hiring mix is heavily research-focused (44 of 57 roles), with emerging investment in engineering infrastructure (GitHub Actions, FastAPI, pytest adoption) to support data pipelines and platform scaling.

Tech Stack 31 technologies

Core StackPyTorch Python TensorFlow MATLAB Docker Terraform NetSuite BigQuery React Jax R JAX Google Workspace HPLC Agilent Coupa Git GCP qPCR LC-MS PyMOL Excel Benchling AlphaFold

AdoptingGitHub Actions Flask FastAPI React C# pytest VBA

What Calico Life Sciences Is Building

◆Challenges

Challenging disease targets
Discovering novel therapeutic targets
Managing complex multi-disciplinary projects
Understanding metabolic mechanisms in aging
Understanding metabolic interactions in health and disease
Ensuring compliance with privacy and export laws
Managing data privacy and security incident response
Random screening
High-quality training data
Computational predictions

▲Active Projects

Protein design
Benchmark development for model validation
Novel drug target identification for age-related cardiovascular diseases
Synthetic route development for drug substance candidates
Technology transfer to contract manufacturing organizations
Hit-to-lead optimization profiling
Preclinical drug discovery pipeline
Process and tool development for pipeline projects
World-class computing and data analysis platform
Clinical trial expense accruals

Hiring Activity

Steady55 roles · 20 in 30d

Department

Research

44

Engineering

3

Data

2

Business

1

Finance

1

Healthcare

1

HR

1

Regulatory

1

Seniority

Senior

19

Principal

9

Intern

8

Director

7

Lead

5

Junior

3

Mid

2

Manager

1

Notable leadership hires: Medical Director, Colony Lead

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About Calico Life Sciences

Calico tackles the fundamental biology of aging through a combination of curiosity-driven discovery science and applied drug development. The company operates across multiple workstreams: protein design and computational target identification (using AlphaFold and JAX), hit-to-lead optimization and synthetic chemistry, preclinical pipeline management, and technology transfer to manufacturing partners. Current projects span novel cardiovascular therapeutic targets, benchmark development for model validation, and a world-class computing and data analysis platform. The organization is structured primarily around research teams, with growing engineering and data functions supporting automation and ML infrastructure.

HeadquartersSouth San Francisco, CA

Company Size201–500 employees

Founded2013

Hiring MarketsUnited States

Frequently Asked Questions

What machine learning frameworks does Calico Life Sciences use?

PyTorch, TensorFlow, JAX, and AlphaFold are all actively in use. The company is adopting GitHub Actions and pytest to strengthen its ML engineering practices.