Clinical-stage biotech developing MASH therapeutics with AI-driven operations
Madrigal is a public biopharmaceutical company developing treatments for metabolic dysfunction-associated steatohepatitis (MASH), a progressive liver disease. The tech stack reveals a company mid-build on AI and data infrastructure—adopting AutoGen, CrewAI, and Langfuse alongside traditional pharma tools (Veeva RIM, dbt, Databricks)—while hiring heavily in healthcare, research, and sales roles at director and senior levels. Active projects span clinical trial execution, regulatory submissions, and real-world evidence generation, aligned with multiple pain points around document efficiency, compliance (SOX 404, TMF archival), and trial scaling.
Notable leadership hires: Health Systems Director, Scientific Director, Medical Director, HR Communications Director, Key Account Director
Madrigal Pharmaceuticals focuses on developing novel therapeutics to halt or reverse liver fibrosis in MASH patients before progression to cirrhosis, liver failure, or cancer. Founded in 2016 and now public, the company operates across 501–1,000 employees based in Conshohocken, Pennsylvania, with hiring in the United States, Switzerland, and Peru. The operational footprint spans clinical development (phase 1–4 trials), regulatory strategy for FDA/BLA submissions, business development, and market access. Core pain points center on workforce alignment, document development efficiency, trial expansion, and supply-chain resilience in a highly regulated environment.
Madrigal develops therapeutics for MASH, a metabolic liver disease. Active work includes phase 1–4 clinical trials, regulatory filings, real-world evidence studies, and marketing to endocrinologists.
Madrigal runs on AutoGen, CrewAI, Databricks, Azure AI, SageMaker, Vertex AI, Veeva RIM (regulatory), dbt, Power BI, Workday, Coupa, NetSuite, and Microsoft cloud services including Fabric and Synapse.
Other companies in the same industry, closest in size