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Prellis Biologics Tech Stack

Lymph node organoid platform for antibody discovery and immunogenicity screening

Biotechnology Research Berkeley, California 11–50 employees Privately Held

Prellis Biologics operates a wet-lab and computational platform (EXIS™) centered on engineered lymph node organoids for high-throughput antibody discovery and immunogenicity assessment. The hiring mix is research-heavy (18 roles) with emerging engineering and data functions, suggesting they're scaling both wet-lab throughput and computational infrastructure to move from manual screening into automation. Active projects span organoid engineering, high-throughput expression, and liquid-handling automation—paired with flagged pain points around expression bottlenecks and data governance—indicating they're hitting the scaling wall that typically forces biotech platforms toward operational maturity.

Tech Stack 36 technologies

Core StackPostgreSQL AWS CloudWatch Python FastAPI SolidWorks Linux Docker 10x Genomics Excel PowerPoint Lynx LC-MS Aurora IAM VPC Benchling Shiny Plotly Dash Spotfire Streamlit R Biacore SDS-PAGE VHDL FPGA C/C++ bash Illumina+6 more

What Prellis Biologics Is Building

Challenges

  • High-throughput expression capabilities
  • Bottlenecks in drug development pipeline
  • Accelerate biotherapeutic discovery
  • Process optimization for improved productivity
  • Lack of structured data platform
  • Data governance challenges
  • Drug development pipeline challenges
  • Scalability of high-throughput sequencing pipelines
  • Industry-wide problems in drug development pipeline
  • Rapid discovery of antibody therapeutic candidates

Active Projects

  • High-throughput antibody screening
  • Mid-scale cloning and expression operations
  • Antibody discovery
  • Lymph node organoid engineering
  • Elisa-based immunoassay development
  • Exis lymph node organoid platform
  • Htp protein expression platform
  • Cell line development workflows
  • Automation of liquid handling workflows
  • Oncology therapeutic area development

Hiring Activity

Accelerating25 roles · 15 in 30d

Department

Research
18
Engineering
2
Data
1
Ops
1
Sales
1

Seniority

Senior
15
Director
2
Junior
2
Mid
2
Principal
2

Notable leadership hires: Oncology Director, Business Development Director

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About Prellis Biologics

Prellis Biologics is a privately held biotech company in Berkeley, California, developing the EXIS™ platform—a modular system that uses engineered lymph node organoids to accelerate antibody discovery, evaluate immunogenicity, and screen vaccine candidates within a single workflow. The company serves antibody therapeutic and immunology research teams. Current operations span wet-lab work (organoid engineering, cell line development, protein expression, ELISA assays) and computational analysis (sequencing, data visualization, bioinformatics). The platform integrates 10x Genomics, LC-MS, Benchling, and in-house tools (Python, FastAPI, Streamlit) for data capture and visualization. Active hiring across research, engineering, and data roles reflects expansion of both discovery capacity and automation infrastructure.

HeadquartersBerkeley, California
Company Size11–50 employees
Hiring MarketsUnited States

Frequently Asked Questions

What is Prellis Biologics' EXIS platform used for?

EXIS™ is an engineered lymph node organoid platform designed for three primary applications: high-throughput human antibody discovery, immunogenicity screening, and vaccine candidate evaluation. The platform consolidates these workflows into a single modular system.

What tech stack does Prellis Biologics use?

Lab instrumentation includes 10x Genomics, LC-MS, Benchling, Biacore, and SDS-PAGE. Data and analysis layers run on Python, FastAPI, Streamlit, Plotly, PostgreSQL, Aurora, and AWS; visualization uses Spotfire and Shiny. Engineering work includes SolidWorks, FPGA, VHDL, and C/C++.

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