S

Singular Genomics Tech Stack

Spatial multiomics sequencing platform for precision diagnostics

Biotechnology Research San Diego, California 201–500 employees Founded 2016 Public Company

Singular Genomics builds hardware and firmware for spatial pathology—specifically the G4X platform, a high-throughput sequencer for in situ multiomics. The tech stack is embedded-heavy (C/C++, RTOS, I2C, UART, CAN, USB protocols) paired with Illumina NovaSeq integration, typical of precision instrumentation. Current hiring is weighted toward director and senior roles in engineering and marketing, with active projects spanning platform firmware, assay development, and demand generation—suggesting a phase shift from product maturation toward market adoption and workflow standardization.

Tech Stack 11 technologies

Core StackIllumina NovaSeq 6000 C/C++ RTOS I2C UART CAN USB Ethernet ImageJ EEPROM RS-232/485

What Singular Genomics Is Building

◆Challenges

Increasing adoption of spatial platform
Assay robustness
Workflow efficiency
Technical challenges

▲Active Projects

G4x spatial platform launch
Digital marketing and demand generation for spatial solutions
G4 sequencing platform firmware development
G4x spatial sequencer firmware development
Spatial multiomics workflows
Assay development and product launch

Hiring Activity

Accelerating6 roles · 3 in 30d

Department

Engineering

2

Marketing

2

Research

1

Seniority

Director

2

Senior

2

Mid

1

Notable leadership hires: Marketing Director

Company intelligence

Find more companies like Singular Genomics by tech stack, pain points and active projects

Get started free

About Singular Genomics

Singular Genomics is a San Diego-based public company founded in 2016 that develops spatial multiomics sequencing instruments for research and clinical diagnostics. The G4X platform is designed to deliver high-throughput in situ analysis, enabling researchers and labs to profile multiple molecular modalities in tissue context. The company's immediate technical priorities include firmware robustness for both the G4 and G4X sequencers, assay optimization for reproducibility, and integration of spatial data workflows. Sales and go-to-market activity center on adoption of the spatial platform among research institutions and diagnostic labs.

HeadquartersSan Diego, California

Company Size201–500 employees

Founded2016

Hiring MarketsUnited States

Frequently Asked Questions

What is Singular Genomics' G4X platform?

The G4X is a high-throughput in situ multiomics sequencer designed for spatial pathology and precision diagnostics. It integrates Illumina NovaSeq technology with Singular's custom firmware and embedded protocols (RTOS, I2C, UART, CAN, USB) to deliver spatial analysis in tissue samples.

What technology does Singular Genomics use?

Singular runs C/C++ firmware on RTOS with embedded protocols (I2C, UART, CAN, USB, Ethernet, RS-232/485). The platform integrates Illumina NovaSeq 6000 sequencers and uses ImageJ for image analysis and EEPROM-based configuration.