Clinical-stage oncology company advancing targeted therapies and ADCs
Immunome is a public clinical-stage oncology company developing targeted cancer therapies, including gamma secretase inhibitors, antibody-drug conjugates (ADCs), and radioligands. The tech stack reveals a regulatory and manufacturing-heavy operation: Veeva CDMS, Medidata Rave, SAS, and NONMEM dominate, paired with analytical chemistry tools (LC-MS/MS, MATLAB). Hiring is senior-skewed (29 senior roles, 15 directors) and concentrated in research, healthcare, and manufacturing—consistent with Phase 3 and Phase 1 trial execution and the imminent commercial launch of varegacestat.
Notable leadership hires: Global Regulatory Lead, CMC Technical Lead, Market Access Director
Immunome develops first-in-class and best-in-class targeted oncology therapies. The pipeline spans three lead programs: varegacestat (gamma secretase inhibitor in Phase 3 for desmoid tumors), IM-1021 (ROR1-targeted ADC in Phase 1), and IM-3050 (FAP-targeted radioligand post-IND clearance), plus preclinical ADC candidates. The company is headquartered in Bothell, Washington, and operates as a public company with 51–200 employees. Active projects center on clinical trial execution, regulatory strategy, drug safety infrastructure, and preparation for the first commercial launch—reflecting transition from development into early-stage commercialization.
Varegacestat (formerly AL102), a gamma secretase inhibitor currently in Phase 3 trials for desmoid tumors. It is the most advanced program and subject of ongoing launch preparation efforts.
Medidata Rave and Veeva CDMS for clinical data management; SAS, R, and NONMEM for statistical programming and pharmacokinetic modeling; LC-MS/MS for analytical chemistry.
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